OVOTRANSFERRIN

OVOTRANSFERRIN, also called conalbumin, is a glycoprotein with a molecular weight of 76,000. OVOTRANSFERRIN comprises approximately 13% of the protein content of egg albumen. More than sixty years ago, researchers determined that OVOTRANSFERRIN is an iron-binding protein, making the iron in a bacterial culture medium nutritionally unavailable to potentially harmful micro-organisms, such as Schigella dysenteria (for which iron is an essential nutrient).

These same investigators later determined that a fraction of human blood serum exerts the same iron-binding action as OVOTRANSFERRIN. This blood serum protein was initially named siderophilin, but today is known as human transferrin. OVOTRANSFERRIN and blood transferrin are now known to have similar amino acid compositions (see table), as well as similar carbohydrate content.

Table: Comparison of Amino Acids Profiles

Amino Acids

Ovotransferrin

Human Transferrin

Bovine Serum Transferrin

Lysine 53 51 52
Histidine 13 19 15
Arginine 33 24 24
Aspartic Acid 77 81 74
Threonine 38 30 44
Serine 46 40 49
Glutamic Acid 62 58 63
Proline 33 30 35
Glycine 58 54 45
Alanine 38 59 49
Half Cystine 12 35 34
Valine 54 43 44
Methionine 10 4 7
Isoleucine 29 14 17
Leucine 51 47 45
Tyrosine 19 24 20
Phenylalanine 27 28 25
Tryptophan 11 9 10

Advantages & benefits

As one of the largest manufacturers and suppliers worldwide of egg white proteins, Bioseutica®’s advanced extraction and purification processes yield products that are consistently chosen over other competitive products. All extraction and refining are done under cGMP guidelines for active pharmaceutical ingredients (API).

An important advantage of using Bioseutica®’s OVOTRANSFERRIN is the elimination of the risk of disease associated with bovine and human-derived transferrins.

Applications

Antibacterial

Among the several protective functions of OVOTRANSFERRIN, the most important one is likely to be the antibacterial activity, which is directly related to the OVOTRANSFERRIN's ability to bind iron (Fe3+), making it unavailable for bacterial growth. This bacteriostatic activity can be enhanced by adding carbonate ion which is one of the iron ligands in the OVOTRANSFERRIN metal binding site increasing the pH from 6 to 8 and immobilizing OVOTRANSFERRIN by covalent linkage to Sepharose 4B [30]. An increase of the bacteriostatic activity towards E. coli O157:H7 as iron chelator was demonstrated using a combination of ovotransferrin, NaHCO3, and EDTA. 

Functional Food

OVOTRANSFERRIN shows a protective function similar to those already ascertained for the homologous mammalian lactoferrin. These additional functions, in many cases not directly related to iron binding, are also displayed by the peptides derived from partial hydrolysis of ovotransferrin. Several defensive properties of OVOTRANSFERRIN are also possessed by its proteolytic fragments, these properties may be of importance for human wellness and its derivatives as dietary additives in normal and pathological human conditions.(1)

Research

Transferrins have been identified as a required media ingredient for the maturation of cells. The role of transferrins in culture systems is to provide iron to cells and to detoxify the media by binding contaminating metal ions, such as zinc, iron, and aluminum in their di and trivalent forms.

Cardiovascular Disease

OVOTRANSFERRIN (OTRF, also referred to as conalbumin) and OTRF-derived peptides, including IRW, IQW, and KVREGT, are, by virtue of their anti-inflammatory and antioxidant characteristics, viable treatment agents for endothelial dysfunction and the prevention of CVD (2).

Skincare

OVOTRANSFERRIN belongs to a group of proteins called metalloproteinases that have been found to induce the production of heat shock proteins (HSPs). Clinical trials with OVOTRANSFERRIN have found that it is able to induce HSPs in the skin, which provides protection against cold stress and other environmental factors. HSPs play a fundamental role in life-essential processes and are associated with many areas of biology and medicine. They are known to help cells disassemble and dispose of damaged proteins and to help in the making and transport of new proteins. The role of HSPs in the aging process is not yet clear. However, the ability of OVOTRANSFERRIN to induce HSP production suggests it can be effectively utilized in personal care skin creams and moisturizers.

Nutrition

OVOTRANSFERRIN, like serum transferrin, is also similar in structure and function to lactoferrin from milk. However, OVOTRANSFERRIN can be extracted in larger quantities and is suitable for use in therapeutic programs. The addition of OVOTRANSFERRIN to cow’s milk (which is generally low in transferrins) enhances its antibacterial property and makes it comparable to human milk.

References

1. Francesco Giansanti, Loris Leboffe, Francesco Angelucci, Giovanni Antonini - The Nutraceutical Properties of Ovotransferrin and Its Potential Utilization as a Functional Food | Publisher Site

2. Shuang Chen, Hongmei Jiang, Hanhui Peng, Xiaosong Wu, and Jun Fang - The Utility of Ovotransferrin and Ovotransferrin-Derived Peptides as Possible Candidates in the Clinical Treatment of Cardiovascular Diseases | Publisher Site

No Warranty: The information contained herein is provided in good faith and, to the best of our knowledge, is true and correct. However, no warranty or guarantee is implied or inferred and the information may be subject to change without further notice. Bioseutica®’s products are sold with the understanding that the purchaser will conduct tests to determine the suitability of these products for their particular use.

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